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Article

Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.

Cell reports. Medicine - 17 Jan 2023

Bader Jakob Maximilian, Deigendesch Nikolaus, Misch Martin, Mann Matthias, Koch Arend, Meissner Felix

Abstract excerpt

High-grade adult-type diffuse gliomas are malignant neuroepithelial tumors with poor survival rates in combined chemoradiotherapy. The current WHO classification is based on IDH1/2 mutational and 1p/19q codeletion status. Glioma proteome alterations remain undercharacterized despite their promise for a better molecular patient stratification and therapeutic target identification. Here, we use mass spectrometry to...

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Identifiers

PMID: 36584682
DOI: 10.1016/j.xcrm.2022.100877
PMCID: PMC9873829

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