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Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein

31 May 2024

Abstract excerpt

The Paramyxoviridae family encompasses medically significant RNA viruses, including human respiroviruses 1 and 3 (RV1, RV3), and zoonotic pathogens like Nipah virus (NiV). RV3, previously known as parainfluenza type 3, for which no vaccines or antivirals have been approved, causes respiratory tract infections in vulnerable populations. The RV3 fusion (F) protein is inherently metastable and will likely require...

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PMID: 38821950
DOI: 10.1038/s41467-024-48059-w

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