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Article

OPRM1 rs2075572 has potential to affect plasma buprenorphine level in opioid users, but not OPRM1 rs562859.

Neuroscience letters - 21 Jun 2024

Kaya-Akyüzlü Dilek, Özkan-Kotiloğlu Selin, Danışman Mustafa, Bal Ceylan

Abstract excerpt

OPRM1 gene encoding mu-opioid receptor (MOR) is the primary candidate gene for buprenorphine (BUP) pharmacogenetics. OPRM1 undergoes alternative splicing leading to multiple MOR subtypes. Thus, in the current study 2 SNPs (rs1799972 and rs562859) were selected due to evidence for their contribution to alternative splicing of OPRM1. The effects of 2 SNPs of OPRM1 gene on plasma buprenorphine and norbuprenorphine...

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PMID: 38821204
DOI: 10.1016/j.neulet.2024.137846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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