Article
Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2016
Tao Chunrong, Simpson Steve, van der Mei Ingrid, Blizzard Leigh, Havrdova Eva, Horakova Dana, Shaygannejad Vahid, Lugaresi Alessandra, Izquierdo Guillermo, Trojano Maria, Duquette Pierre, Girard Marc, Grand'Maison Franois, Grammond Pierre, Alroughani Raed, Terzi Murat, Oreja-Guevara Celia, Sajedi Seyed Aidin, Iuliano Gerardo, Sola Patrizia, Lechner-Scott Jeannette, Pesch Vincent Van, Pucci Eugenio, Bergamaschi Roberto, Barnett Michael, Ramo Cristina, Singhal Bhim, LA Spitaleri Daniele, Slee Mark, Verheul Freek, Fernández Bolaños Ricardo, Amato Maria Pia, Cristiano Edgardo, Granella Franco, Hodgkinson Suzanne, Fiol Marcela, Gray Orla, McCombe Pamela, Saladino Maria Laura, Sánchez Menoyo José Luis, Shuey Neil, Vucic Steve, Shaw Cameron, Deri Norma, Arruda Walter Oleschko, Butzkueven Helmut, Spelman Tim, Taylor Bruce V
Abstract excerpt
BACKGROUND: Age at onset (AAO) in multiple sclerosis (MS) is an important marker of disease severity and may have prognostic significance. Understanding what factors can influence AAO may shed light on the aetiology of this complex disease, and have applications in the diagnostic process. METHODS: The study cohort of 22 162 eligible patients from 21 countries was extracted from the MSBase registry. Only patients...
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