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CRISPR/Cas-based CAR-T cells: production and application

30 May 2024

Abstract excerpt

Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by retroviral or lentiviral vectors. However, the random insertion of CARs can lead to issues like clonal expansion, oncogenic transformation, variegated transgene expression, and transcriptional silencing. The...

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PMID: 38816881
DOI: 10.1186/s40364-024-00602-z

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