Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.

PLoS pathogens - 1 Apr 2018

Kumar Amit, Smith Claire E P, Giorgi Elena E, Eudailey Joshua, Martinez David R, Yusim Karina, Douglas Ayooluwa O, Stamper Lisa, McGuire Erin, LaBranche Celia C, Montefiori David C, Fouda Genevieve G, Gao Feng, Permar Sallie R

Abstract excerpt

Despite extensive genetic diversity of HIV-1 in chronic infection, a single or few maternal virus variants become the founders of an infant's infection. These transmitted/founder (T/F) variants are of particular interest, as a maternal or infant HIV vaccine should raise envelope (Env) specific IgG responses capable of blocking this group of viruses. However, the maternal or infant factors that contribute to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Infections

Share to Infectious Disease Transmission, Vertical

Share to Neutralization Tests

Share to Plasma

Share to Pregnancy Complications, Infectious

Source

Open in PubMed Open full text

Identifiers

PMID: 29672607
DOI: 10.1371/journal.ppat.1006944
PMCID: PMC5908066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.PMID 29672607Read ↗

Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers.Semantic proximity Read ↗

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.Semantic proximity Read ↗

Role of Maternal Autologous Neutralizing Antibody in Selective Perinatal Transmission of Human Immunodeficiency Virus Type 1 Escape VariantsSemantic proximity Read ↗

Genotypic and functional properties of early infant HIV-1 envelopesSemantic proximity Read ↗

Envelope glycoproteins of human immunodeficiency virus type 1 variants issued from mother-infant pairs display a wide spectrum of biological properties.Semantic proximity Read ↗

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.Semantic proximity Read ↗

Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission.Semantic proximity Read ↗

Neutralizing antibody escape during HIV-1 mother-to-child transmission involves conformational masking of distal epitopes in envelope.Semantic proximity Read ↗

The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not Driven by Selection of Especially Neutralization-Resistant Virus from the Maternal Viral PopulationSemantic proximity Read ↗

HIV-1-specific CD8+ T cell responses and viral evolution in women and infants.Semantic proximity Read ↗

Viral Suppression and Resistance in a Cohort of Perinatally-HIV Infected (PHIV+) Pregnant Women.Semantic proximity Read ↗

Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.