Article
Diseases associated with genomic imprinting.
Progress in molecular biology and translational science - 1 Jan 2011
Wilkins Jon F, Úbeda Francisco
Abstract excerpt
Genomic imprinting is the phenomenon where the expression of a locus differs between the maternally and paternally inherited alleles. Typically, this manifests as transcriptional silencing of one of the alleles, although many genes are imprinted in a tissue- or isoform-specific manner. Diseases associated with imprinted genes include various cancers, disorders of growth and metabolism, and disorders in...
Topics
- Genetic Predisposition to Disease
- Genomic Imprinting
- Humans
- Mental Disorders