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Inhibition of HECT E3 ligases as potential therapy for COVID-19

24 Mar 2021

Abstract excerpt

SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of the HECT-E3 ligase family members has been implicated in the cell egression phase of deadly RNA viruses such as Ebola through direct interaction of its VP40 Protein. Here we report that HECT-E3 ligase family members such as NEDD4 and...

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PMID: 33762578
DOI: 10.1038/s41419-021-03513-1

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