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Article

Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.

Cell reports - 31 Aug 2021

Duan Xiuying, Xu Lingna, Li Yawen, Jia Lijun, Liu Wei, Shao Wenxia, Bayat Vafa, Shang Weina, Wang Liquan, Liu Jun-Ping, Tong Chao

Abstract excerpt

The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss of dTBC1D22, an essential gene that encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in lipid droplet accumulation in multiple tissues. We observe that dTBC1D22 interacts with Rab40 and exhibits GTPase activating protein (GAP) activity. Overexpression of either the GTP- or...

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PMID: 34469730
DOI: 10.1016/j.celrep.2021.109541

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