Article

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

2023-09-01

Abstract excerpt

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages they offer are compromised with aging. Here, we show that treating mice with estrogen (E2), a hormone that decreases with age, to mice can counteract the aging- related decline in beige adipocyte formation when subjected to cold, while concurrently enhancing energy expend...

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Identifiers and source

Literature Corpus work: 8f1055a6-4185-5c36-9eb7-773f162dc992
DOI: 10.1101/2023.08.31.555821

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