Article
Population-based nanopore sequencing of the HIV-1 pangenome to identify drug resistance mutations.
Scientific reports - 27 May 2024
Ode Hirotaka, Matsuda Masakazu, Shigemi Urara, Mori Mikiko, Yamamura Yoshimi, Nakata Yoshihiro, Okazaki Reiko, Kubota Mai, Setoyama Yuka, Imahashi Mayumi, Yokomaku Yoshiyuki, Iwatani Yasumasa
Abstract excerpt
HIV-1 drug resistance genotypic tests have primarily been performed by Sanger sequencing of gene segments encoding different drug target proteins. Since the number of targets has increased with the addition of a new class of antiretroviral drugs, a simple high-throughput system for assessing nucleotide sequences throughout the HIV-1 genome is required. Here, we developed a new solution using nanopore sequencing...
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