Article
Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study.
Diabetes care - 1 Apr 2023
Chen Jie, Yuan Shuai, Fu Tian, Ruan Xixian, Qiao Jie, Wang Xiaoyan, Li Xue, Gill Dipender, Burgess Stephen, Giovannucci Edward L, Larsson Susanna C
Abstract excerpt
OBJECTIVE: We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). RESEARCH DESIGN AND METHODS: Uncorrelated genetic variants associated with type 2 diabetes (n = 231), fasting insulin (n = 38), fasting glucose (n = 71), and hemoglobin A1c (n = 75) at the genome-wide significance were selected as instrument...
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