Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.

doi:10.1158/1055-9965.EPI-09-0223

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Article

Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2009

Collin Simon M, Metcalfe Chris, Zuccolo Luisa, Lewis Sarah J, Chen Lina, Cox Angela, Davis Michael, Lane J Athene, Donovan Jenny, Smith George Davey, Neal David E, Hamdy Freddie C, Gudmundsson Julius, Sulem Patrick, Rafnar Thorunn, Benediktsdottir Kristrun R, Eeles Rosalind A, Guy Michelle, Kote-Jarai Zsofia, Morrison Jonathan, Al Olama Ali Amin, Stefansson Kari, Easton Douglas F, Martin Richard M

Abstract excerpt

Folate-pathway gene polymorphisms have been implicated in several cancers and investigated inconclusively in relation to prostate cancer. We conducted a systematic review, which identified nine case-control studies (eight included, one excluded). We also included data from four genome-wide association studies and from a case-control study nested within the UK population-based Prostate Testing for Cancer and...

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Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19706844
DOI: 10.1158/1055-9965.EPI-09-0223

Genes

MTHFR
MTR
SHMT1
FOLH1
MTHFD1
MTRR
RFC1

Variants

rs1801133
rs1801133
rs1801133
rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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rs1801133