Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

doi:10.1038/nbt.3587

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Article

Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

Nature biotechnology - 1 Aug 2016

Alexandrov Vadim, Brunner Dani, Menalled Liliana B, Kudwa Andrea, Watson-Johnson Judy, Mazzella Matthew, Russell Ian, Ruiz Melinda C, Torello Justin, Sabath Emily, Sanchez Ana, Gomez Miguel, Filipov Igor, Cox Kimberly, Kwan Mei, Ghavami Afshin, Ramboz Sylvie, Lager Brenda, Wheeler Vanessa C, Aaronson Jeff, Rosinski Jim, Gusella James F, MacDonald Marcy E, Howland David, Kwak Seung

Abstract excerpt

Rapid technological advances for the frequent monitoring of health parameters have raised the intriguing possibility that an individual's genotype could be predicted from phenotypic data alone. Here we used a machine learning approach to analyze the phenotypic effects of polymorphic mutations in a mouse model of Huntington's disease that determine disease presentation and age of onset. The resulting model...

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PMID: 27376585
DOI: 10.1038/nbt.3587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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