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Article

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.

mBio - 22 Aug 2017

Menachery Vineet D, Mitchell Hugh D, Cockrell Adam S, Gralinski Lisa E, Yount Boyd L, Graham Rachel L, McAnarney Eileen T, Douglas Madeline G, Scobey Trevor, Beall Anne, Dinnon Kenneth, Kocher Jacob F, Hale Andrew E, Stratton Kelly G, Waters Katrina M, Baric Ralph S

Abstract excerpt

While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28830941
DOI: 10.1128/mBio.00665-17
PMCID: PMC5565963

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