IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.

doi:10.1073/pnas.2310864121

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Article

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 2024

Röwekamp Ivo, Maschirow Laura, Rabes Anne, Fiocca Vernengo Facundo, Hamann Lutz, Heinz Gitta Anne, Mashreghi Mir-Farzin, Caesar Sandra, Milek Miha, Fagundes Fonseca Anna Carolina, Wienhold Sandra-Maria, Nouailles Geraldine, Yao Ling, Mousavi Soraya, Bruder Dunja, Boehme Julia D, Puzianowska-Kuznicka Monika, Beule Dieter, Witzenrath Martin, Löhning Max, Klose Christoph S N, Heimesaat Markus M, Diefenbach Andreas, Opitz Bastian

Abstract excerpt

IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals and that single-nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect...

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Identifiers

PMID: 38781213
DOI: 10.1073/pnas.2310864121
PMCID: PMC11145264

Genes

IL33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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