IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

Abstract excerpt

<h4>ABSTRACT</h4> IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals, and that single nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia i...

Topics

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• Gastrointestinal Microbiome
• Interleukin-1 Receptor-Like 1 Protein
• Interleukin-22
• Interleukin-33
• Interleukins
• Microbiota
• Pneumonia, Pneumococcal
• Streptococcus pneumoniae

Identifiers and source

Literature Corpus work

4cd57398-61d1-5d9e-b843-737bf38c4e1e

DOI

10.1101/2023.07.19.549679