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Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography

21 May 2024

Abstract excerpt

ABSTRACT: Epigenetics has gained considerable interest as potential mediators of molecular alterations that could underlie the prolonged sensitization of nociceptors, neurons, and glia in response to various environmental stimuli. Histone acetylation and deacetylation, key processes in modulating chromatin, influence gene expression; elevated histone acetylation enhances transcriptional activity, whereas...

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PMID: 38776171
DOI: 10.1097/j.pain.0000000000003272

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