Article

Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition

2020-04-22

Abstract excerpt

Migraine is the third most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by deacetylating its primary substrate, α-tubulin. We use validated models of migraine to show that HDAC6-inhibition is...

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Literature Corpus work: b996f25b-d95b-50ec-ab54-92a5a5575905
DOI: 10.1101/2020.04.21.053272

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