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Article

DNA Methylation of SPARC and Chronic Low Back Pain

1 Jan 2011

Abstract excerpt

BACKGROUND: The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein expression is decreased as a function of age and disc degeneration. In mice, inactivation of the SPARC gene results in the development of accelerated age-dependent disc degeneration concurrent with...

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PMID: 21867537
DOI: 10.1186/1744-8069-7-65

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