Article
Phenotype matters: the absence of a positive association between cortical thinning and chronic low back pain when controlling for salient clinical variables.
The Clinical journal of pain - 1 Oct 2014
Dolman Andrew J, Loggia Marco L, Edwards Robert R, Gollub Randy L, Kong Jian, Napadow Vitaly, Wasan Ajay D
Abstract excerpt
AIMS/OBJECTIVES/BACKGROUND: Studies have associated chronic low back pain (cLBP) with grey matter thinning. But these studies have not controlled for important clinical variables (such as a comorbid affective disorder, pain medication, age, or pain phenotype), which may reduce or eliminate these associations. METHODS: We conducted cortical thickness and voxel-based morphometry (VBM) analyses in 14 cLBP patients...
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