Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.

Abstract excerpt

Many different ion channel pores are thought to have charged amino acid residues clustered around their entrances. The so-called surface charges contributed by these residues can play important roles in attracting oppositely charged ions from the bulk solution on one side of the membrane, increasing effective local counterion concentration and favoring rapid ion movement through the channel. Here we use...

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