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Article

Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.

The Journal of physiology - 1 Jun 2003

Gong Xiandi, Linsdell Paul

Abstract excerpt

Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is blocked by highly lyotropic permeant anions which bind tightly within the pore. Here we show that several different substitutions of a positively charged amino acid residue, arginine R334, in the putative outer mouth of the CFTR pore, greatly reduce the block caused by lyotropic Au(CN)2- ions applied to the...

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Source

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Identifiers

PMID: 12679372
DOI: 10.1113/jphysiol.2002.038232
PMCID: PMC2342941

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.PMID 12679372Read ↗

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Semantic proximity Read ↗

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.Semantic proximity Read ↗

Interactions between permeant and blocking anions inside the CFTR chloride channel pore.Semantic proximity Read ↗

Trivalent anions as probes of the CFTR channel pore.Semantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.Semantic proximity Read ↗

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns.Semantic proximity Read ↗

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.Semantic proximity Read ↗

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Semantic proximity Read ↗

A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block.Semantic proximity Read ↗

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