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Article

Anion conductance selectivity mechanism of the CFTR chloride channel.

Biochimica et biophysica acta - 1 Apr 2016

Linsdell Paul

Abstract excerpt

All ion channels are able to discriminate between substrate ions to some extent, a process that involves specific interactions between permeant anions and the so-called selectivity filter within the channel pore. In the cystic fibrosis transmembrane conductance regulator (CFTR) anion-selective channel, both anion relative permeability and anion relative conductance are dependent on anion free energy of...

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Source

Identifiers

PMID: 26779604
DOI: 10.1016/j.bbamem.2016.01.009

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anion conductance selectivity mechanism of the CFTR chloride channel.PMID 26779604Read ↗

Structural identification of a selectivity filter in CFTRSemantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns.Semantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.Semantic proximity Read ↗

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.Semantic proximity Read ↗

Interactions between permeant and blocking anions inside the CFTR chloride channel pore.Semantic proximity Read ↗

Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate.Semantic proximity Read ↗

Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.Semantic proximity Read ↗

Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Semantic proximity Read ↗

Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.Semantic proximity Read ↗

Mechanism of direct bicarbonate transport by the CFTR anion channel.Semantic proximity Read ↗

Ion conduction and selectivity in acid-sensing ion channel 1.Semantic proximity Read ↗

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