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Article

Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns.

The Journal of general physiology - 1 Dec 1999

Smith S S, Steinle E D, Meyerhoff M E, Dawson D C

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel exhibits lyotropic anion selectivity. Anions that are more readily dehydrated than Cl exhibit permeability ratios (P(S)/P(Cl)) greater than unity and also bind more tightly in the channel. We compared the selectivity of CFTR to that of a synthetic anion-selective membrane [poly(vinyl chloride)-tridodecylmethylammonium chloride; PVC-TDMAC]...

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Source

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Identifiers

PMID: 10578016
DOI: 10.1085/jgp.114.6.799
PMCID: PMC2230651

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns.PMID 10578016Read ↗

Anion conductance selectivity mechanism of the CFTR chloride channel.Semantic proximity Read ↗

Structural identification of a selectivity filter in CFTRSemantic proximity Read ↗

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.Semantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

Macromolecular interactions and ion transport in cystic fibrosis.Semantic proximity Read ↗

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.Semantic proximity Read ↗

K+ channel selectivity depends on kinetic as well as thermodynamic factors.Semantic proximity Read ↗

Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Semantic proximity Read ↗

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5.Semantic proximity Read ↗

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Semantic proximity Read ↗

Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology.Semantic proximity Read ↗

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