Article
Integrating Reinforcement Learning and Monte Carlo Tree Search for enhanced neoantigen vaccine design.
Briefings in bioinformatics - 27 Mar 2024
Lin Yicheng, Ma Jiakang, Yuan Haozhe, Chen Ziqiang, Xu Xingyu, Jiang Mengping, Zhu Jialiang, Meng Weida, Qiu Wenqing, Liu Yun
Abstract excerpt
Recent advances in cancer immunotherapy have highlighted the potential of neoantigen-based vaccines. However, the design of such vaccines is hindered by the possibility of weak binding affinity between the peptides and the patient's specific human leukocyte antigen (HLA) alleles, which may not elicit a robust adaptive immune response. Triggering cross-immunity by utilizing peptide mutations that have enhanced...
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