Article

Computational design of HLA class I superbinders for broad T cell immunogenicity

2025-07-15

Abstract excerpt

Human leukocyte antigen (HLA) class I molecules are highly polymorphic, restricting peptide binding to narrow sequence subsets. Designing peptides that bind multiple HLA supertypes— termed superbinders—offers a promising strategy for broad-spectrum T-cell vaccines and immunotherapies. Here we present superHLA, a computational framework that combines Markov Chain Monte Carlo optimization with state-of-the-art MHC b...

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Literature Corpus work: 795a7141-baf7-5a17-960f-4c34ba477c09
DOI: 10.1101/2025.07.10.664084

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