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Article

NeoAgDT: optimization of personal neoantigen vaccine composition by digital twin simulation of a cancer cell population.

Bioinformatics (Oxford, England) - 2 May 2024

Mösch Anja, Grazioli Filippo, Machart Pierre, Malone Brandon

Abstract excerpt

MOTIVATION: Neoantigen vaccines make use of tumor-specific mutations to enable the patient's immune system to recognize and eliminate cancer. Selecting vaccine elements, however, is a complex task which needs to take into account not only the underlying antigen presentation pathway but also tumor heterogeneity. RESULTS: Here, we present NeoAgDT, a two-step approach consisting of: (i) simulating individual cancer...

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Identifiers

PMID: 38614133
DOI: 10.1093/bioinformatics/btae205
PMCID: PMC11076149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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