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Article

Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2024

Ye Matthew T, Zuo Zhuang, Calin Steliana, Ye Fengxi, He Hua, Kamata Wataru, Yang Yaling, You M James

Abstract excerpt

PURPOSE: STAT3 is a key transcription factor that mediates cancer progression through phosphorylation or gain-of-function mutations. STAT3 activation in myeloid neoplasms (MN) is primarily mediated through phosphorylation. STAT3 mutation has only rarely been reported in MNs. EXPERIMENTAL DESIGN: We assessed the clinicopathologic and molecular genetic features of 32 STAT3-mutated MNs. RESULTS: The frequency of...

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Aged
Aged, 80 and over
Genetic Association Studies
Leukemia, Myeloid, Acute
Leukemia, Myelomonocytic, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Myeloproliferative Disorders

STAT3 Transcription Factor

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PMID: 38767620
DOI: 10.1158/1078-0432.CCR-24-0066

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