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Article

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

10 May 2007

Abstract excerpt

Severe congenital neutropenia (SCN) is an inborn disorder of granulopoiesis. Like most other bone marrow failure syndromes, it is associated with a marked propensity to transform into a myelodysplastic syndrome (MDS) or acute leukemia, with a cumulative rate of transformation to MDS/leukemia that exceeds 20%. The genetic (and/or epigenetic) changes that contribute to malignant transformation in SCN are largely...

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Identifiers

PMID: 17494858
DOI: 10.1182/blood-2007-03-081216

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