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Article

STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia

6 Nov 2014

Abstract excerpt

STAT3 is important for transcriptional regulation in human acute myeloid leukemia (AML). STAT3 has thousands of potential DNA binding sites but usually shows cell type specific binding preferences to a limited number of these. Furthermore, AML is a very heterogeneous disease, and studies of the prognostic impact of STAT3 in human AML have also given conflicting results. A more detailed characterization of STAT3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25374305
DOI: 10.1586/17474086.2015.971005

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