Article
Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.
Expert opinion on therapeutic targets - 1 Jan 2018
Orlova Anna, Wingelhofer Bettina, Neubauer Heidi A, Maurer Barbara, Berger-Becvar Angelika, Keserű György Miklós, Gunning Patrick T, Valent Peter, Moriggl Richard
Abstract excerpt
INTRODUCTION: Hematopoietic neoplasms are often driven by gain-of-function mutations of the JAK-STAT pathway together with mutations in chromatin remodeling and DNA damage control pathways. The interconnection between the JAK-STAT pathway, epigenetic regulation or DNA damage control is still poorly understood in cancer cell biology. Areas covered: Here, we focus on a broader description of mutational insights...
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