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Article

Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990-2020.

PLoS computational biology - 1 Aug 2022

Flegg Jennifer A, Humphreys Georgina S, Montanez Brenda, Strickland Taryn, Jacome-Meza Zaira J, Barnes Karen I, Raman Jaishree, Guerin Philippe J, Hopkins Sibley Carol, Dahlström Otienoburu Sabina

Abstract excerpt

BACKGROUND: Sulfadoxine-pyrimethamine (SP) is recommended in Africa in several antimalarial preventive regimens including Intermittent Preventive Treatment in pregnant women (IPTp), Intermittent Preventive Treatment in infants (IPTi) and Seasonal Malaria Chemoprevention (SMC). The effectiveness of SP-based preventive treatments are threatened in areas where Plasmodium falciparum resistance to SP is high. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35951528
DOI: 10.1371/journal.pcbi.1010317
PMCID: PMC9371298

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