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Persistent and Circulating Plasmodium falciparum dhfr and dhps Mutations in Busia County, Western Kenya.

Pathogens (Basel, Switzerland) - 20 Feb 2026

Ndung'u Loise, Thiong'o Kelvin, Karani Lewis, Gitahi Stephen, Kimani Francis, Ngugi Mathew Piero, Kiboi Daniel

Abstract excerpt

Malaria in pregnancy remains a major driver of poor maternal and neonatal health outcomes in sub-Saharan Africa. For decades, intermittent preventive treatment in pregnancy (IPTp), with sulphadoxine-pyrimethamine (SP), has mitigated malaria-associated health risks, but concerns have been raised regarding accumulated Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations...

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Antimalarials
Dihydropteroate Synthase
Drug Combinations
Kenya
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetrahydrofolate Dehydrogenase

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PMID: 41754485
DOI: 10.3390/pathogens15020233
PMCID: PMC12943605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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