Article
Disparate selection of mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium ovale curtisi and P. o. wallikeri in Africa.
PLoS neglected tropical diseases - 1 Dec 2022
Chen Jing, Ma Xiaoqin, Tang Jianxia, Xu Sui, Gu Yaping, Tang Feng, Cao Yuanyuan, Wang Weiming, Zhou Huayun, Zhang Jiayao, Yu Xinyu, Zhu Guoding, Zhu Meng, Zhang Qingfeng, Culleton Richard, Liu Yaobao, Cao Jun
Abstract excerpt
Plasmodium ovale curtisi and P. ovale wallikeri are both endemic in sub-Saharan Africa, the Middle East and Southeast Asia. Molecular surveillance data for drug resistance in P. ovale spp. is limited at present. We analysed polymorphisms in the podhfr, pocrt and pocytb genes of P. ovale spp. in 147 samples collected from travelers returning to China from Africa. Two podhfr mutations, S58R and S113N/T were...
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