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Article

Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set.

Neurobiology of aging - 1 Jun 2016

Ghani Mahdi, Sato Christine, Kakhki Erfan Ghani, Gibbs J Raphael, Traynor Bryan, St George-Hyslop Peter, Rogaeva Ekaterina

Abstract excerpt

Genome wide association studies have identified an association between Alzheimer's disease (AD) and common polymorphisms in the MS4A and TREM loci (each containing a cluster of homologous genes) and should be thoroughly investigated for the presence of potentially functional variations. We conducted a mutation analysis by next generation sequencing of 15 genes within the MS4A and TREM gene clusters; and...

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Source

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Identifiers

PMID: 27084067
DOI: 10.1016/j.neurobiolaging.2016.03.009
PMCID: PMC8985522

Genes

TREM2
TREML1
TREML2
TREML4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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