TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.

doi:10.1177/03946320241257241

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Article

TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.

International journal of immunopathology and pharmacology - 1 Jan 2000

Benmansour R, Tagajdid M R, El Hamzaoui H, Fjouji S, Doghmi N, Houba A, Belbacha I, Elkochri S, Aabi R, Elannaz H, Laraqui A, El Mchichi B, Chmitah T, Touil N, Ennibi K, Eljaoudi R, Elmir E, Amine Lahlou I, Oumzil H

Abstract excerpt

OBJECTIVES: This study aimed to explore the potential correlation between specific single nucleotide polymorphisms (TYK2, IFITM3, IFNAR2, and OAS3 variants) and the severity of COVID-19 in Moroccan patients. METHODS: A genetic analysis was conducted on 109 patients with PCR-confirmed SARS-CoV-2 infection in Morocco. Among these patients, 46% were hospitalized in the intensive care unit, while 59% were not...

Topics

Adult
Aged
Female
Humans
Male
Middle Aged
2',5'-Oligoadenylate Synthetase
COVID-19
Genetic Predisposition to Disease
Intensive Care Units

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Morocco

Polymorphism, Single Nucleotide

Receptor, Interferon alpha-beta

RNA-Binding Proteins

SARS-CoV-2

Severity of Illness Index

TYK2 Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 38760017
DOI: 10.1177/03946320241257241
PMCID: PMC11102656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38760017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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