Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables.

doi:10.1038/s41598-024-71476-2

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Article

Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables.

Scientific reports - 5 Sept 2024

Delgado-Wicke Pablo, Fernández de Córdoba-Oñate Sara, Roy-Vallejo Emilia, Alegría-Carrasco Estíbaliz, Rodríguez-Serrano Diego A, Lamana Amalia, Montes Nuria, Nicolao-Gómez Ana, Carracedo-Rodríguez Rosa, Marcos-Jiménez Ana, Díaz-Fernández Paula, Galván-Román José M, Rabes-Rodríguez Laura, Sanz-Alba Marta, Álvarez-Rodríguez Jesús, Villa-Martí Almudena, Rodríguez-Franco Carlos, Villapalos-García Gonzalo, Zubiaur Pablo, Abad-Santos Francisco, de Los Santos Ignacio, Gomariz Rosa P, García-Vicuña Rosario, Muñoz-Calleja Cecilia, González-Álvaro Isidoro, Fernández-Ruiz Elena

Abstract excerpt

The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (TYK2, STAT1, STAT4, OAS1, SOCS) and the...

Topics

Humans
COVID-19
Male
Female
Polymorphism, Single Nucleotide
Middle Aged
Severity of Illness Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

SARS-CoV-2

Aged

Adult

Toll-Like Receptor 7

TYK2 Kinase

Genotype

Genetic Predisposition to Disease

2',5'-Oligoadenylate Synthetase

Source

Open in PubMed Open full text

Identifiers

PMID: 39237611
DOI: 10.1038/s41598-024-71476-2
PMCID: PMC11377536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39237611-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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