Article
Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality.
Genomics - 1 Jul 2021
Alghamdi Jahad, Alaamery Manal, Barhoumi Tlili, Rashid Mamoon, Alajmi Hala, Aljasser Nasser, Alhendi Yaseen, Alkhalaf Hind, Alqahtani Hanadi, Algablan Omer, Alshaya Abdulraham I, Tashkandi Nabiha, Massadeh Salam, Almuzzaini Bader, Ehaideb Salleh N, Bosaeed Mohammad, Ayoub Kamal, Yezli Saber, Khan Anas, Alaskar Ahmed, Bouchama Abderrezak
Abstract excerpt
Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%....
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