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Article

HLA allelic variation and COVID-19 severity in a Kuwait-based population: a high-resolution immunogenetic study.

Frontiers in immunology - 1 Jan 2026

Alrukhayes Monera, Al-Shatti Nada, Alhasawi Almunther, Alghubayshi Omar, Almsned Fahad, Eissa Mariam M Al

Abstract excerpt

Background: Human leukocyte antigen (HLA) polymorphisms play a vital role in antiviral immunity, but their influence on COVID-19 severity differs significantly among ethnic groups. T-cell responses are essential for clearing SARS-CoV-2, yet the immunogenetic factors underlying the diverse clinical outcomes in COVID-19, especially in certain populations, are not fully understood. In a Kuwait-based cohort from...

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Topics

Humans
Male
Female
Kuwait
Middle Aged
HLA Antigens
COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Severity of Illness Index

SARS-CoV-2

Alleles

Adult

Genetic Predisposition to Disease

Aged

Genotype

Gene Frequency

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42774373
DOI: 10.3389/fimmu.2026.1832089
PMCID: PMC13593864

Genes

ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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