Article
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Genes - 22 Dec 2022
Dieter Cristine, de Almeida Brondani Leticia, Lemos Natália Emerim, Schaeffer Ariell Freires, Zanotto Caroline, Ramos Denise Taurino, Girardi Eliandra, Pellenz Felipe Mateus, Camargo Joiza Lins, Moresco Karla Suzana, da Silva Lucas Lima, Aubin Mariana Rauback, de Oliveira Mayara Souza, Rech Tatiana Helena, Canani Luís Henrique, Gerchman Fernando, Leitão Cristiane Bauermann, Crispim Daisy
Abstract excerpt
Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain the inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19 severity; however, the results are inconclusive. Thus, we investigated the association between polymorphisms in ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4,...
Topics
- Humans
- Male
- Female
- COVID-19
- Interferon-Induced Helicase, IFIH1
- Polymorphism, Genetic
- Genotype
- Disease Progression
- TYK2 Kinase