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Article

AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity.

Journal of molecular biology - 15 Jun 2024

Wang Xueqian, Wang Yu, Cai Qixu, Zhang Mingjie

Abstract excerpt

AIDA-1, encoded by ANKS1B, is an abundant postsynaptic scaffold protein essential for brain development. Mutations of ANKS1B are closely associated with various psychiatric disorders. However, very little is known regarding the molecular mechanisms underlying AIDA-1's involvements under physiological and pathophysiological conditions. Here, we discovered an interaction between AIDA-1 and the SynGAP family...

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Source

Identifiers

PMID: 38759928
DOI: 10.1016/j.jmb.2024.168608

Genes

AIDA
SYNGAP1

Provenance

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