Article
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
Human molecular genetics - 15 Mar 2015
Francelle Laetitia, Galvan Laurie, Gaillard Marie-Claude, Guillermier Martine, Houitte Diane, Bonvento Gilles, Petit Fanny, Jan Caroline, Dufour Noëlle, Hantraye Philippe, Elalouf Jean-Marc, De Chaldée Michel, Déglon Nicole, Brouillet Emmanuel
Abstract excerpt
The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here, we studied the striatal protein µ-crystallin (Crym). Crym is the NADPH-dependent p38 cytosolic T3-binding protein...
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