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The amino acid variation at hemagglutinin sites 145, 153, 164 and 200 modulate antigenicity andreplication of H9N2 avian influenza virus.

Veterinary microbiology - 1 Sept 2024

Wu Jinsen, Wan Zhimin, Qian Kun, Shao Hongxia, Ye Jianqiang, Qin Aijian

Abstract excerpt

H9N2 avian influenza virus (AIV), one of the predominant subtypes circulating in the poultry industry, inflicts substantial economic damage. Mutations in the hemagglutinin (HA) and neuraminidase (NA) proteins of H9N2 frequently alter viral antigenicity and replication. In this paper, we analyzed the HA genetic sequences and antigenic properties of 26 H9N2 isolates obtained from chickens in China between 2012 and...

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Identifiers

PMID: 39018942
DOI: 10.1016/j.vetmic.2024.110188

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