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Article

Dominant HA motif 131/132-NT shapes the phenotype of avian H9N2 influenza virus by modulating agglutination property, receptor specificity and infectivity in animals.

Virologica Sinica - 1 Jun 2026

Chen Xue, Dong Jinze, Zhao Chuankuo, Wang Linlin, Gao Xinyang, Li Zhixin, Sun Honglei, Sun Yipeng, Liu Jinhua, Zhang Rui, Pu Juan

Abstract excerpt

H9N2 avian influenza viruses (AIVs), which are enzootic in poultry and possess spillover potential to humans, represent a considerable global public health threat. Since 2021, we have observed an unprecedented decline in the ability of H9N2 viruses to agglutinate chicken red blood cells (CRBCs), a change that impairs effective detection in routine surveillance. Substituting CRBCs with turkey or guinea pig...

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Identifiers

PMID: 42288138
DOI: 10.1016/j.virs.2026.06.007
PMCID: PMC13469311

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