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Genetic polymorphisms in IL-2, IL-10 and FOXP3 are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort.

Scandinavian journal of immunology - 1 Aug 2024

Kløve-Mogensen Kirstine, Steffensen Rudi, Masmas Tania Nicole, Glenthøj Andreas, Jensen Christina Friis, Ratcliffe Paul, Höglund Petter, Hasle Henrik, Nielsen Kaspar René, Haunstrup Thure Mors

Abstract excerpt

Autoimmune neutropenia (AIN) in early childhood is characterized by chronic neutropenia and positivity for human neutrophil antibodies (HNA), resulting in the excessive destruction of neutrophils. The association between regulatory T cells (Tregs) and AIN has been described, and in this study, we investigated three Treg-associated genes, IL-2, IL-10 and FOXP3. The frequencies of three single nucleotide...

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PMID: 38750640
DOI: 10.1111/sji.13374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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