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Article

Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors.

Leukemia & lymphoma - 1 Dec 2017

Mastrodemou Semeli, Stalika Evangelia, Vardi Anna, Gemenetzi Katerina, Spanoudakis Michalis, Karypidou Maria, Mavroudi Irene, Hadzidimitriou Anastasia, Stavropoulos-Giokas Catherine, Papadaki Helen A, Stamatopoulos Kostas

Abstract excerpt

Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by female predominance and mostly uncomplicated course. Crucial to CIN pathophysiology is the presence of activated T lymphocytes with myelosuppressive properties in both peripheral blood (PB) and bone marrow (BM). We systematically profiled the T cell receptor beta chain (TRB) gene repertoire in CD8+ cells of 34 CIN...

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Source

Identifiers

PMID: 28535087
DOI: 10.1080/10428194.2017.1324154

Genes

TRB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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