Article
Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels.
Biochemical and biophysical research communications - 24 Sept 1999
Gao P S, Mao X Q, Jouanguy E, Pallier A, Döffinger R, Tanaka Y, Nakashima H, Otsuka T, Roberts M H, Enomoto T, Dake Y, Kawai M, Sasaki S, Shaldon S R, Coull P, Adra C N, Niho Y, Casanova J L, Shirakawa T, Hopkin J M
Abstract excerpt
Atopy is an immune disorder in which a Th2 dominant mechanism leads to high IgE levels and the clinical disorder asthma. It has been postulated that the Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. However, neither murine nor human variants of IFNgamma...
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