Article
Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling.
Clinical and experimental medicine - 1 Dec 2023
Liu Rong, Guo Yibing, Han Lin, Feng Shunqiao, Cao Jing, Sun Yanling, Cao Zhenhua, Cui Xiaodai
Abstract excerpt
ARAF mutations have been identified in a limited subset of patients with Langerhans cell histiocytosis (LCH), a rare disorder characterized by abnormal proliferation of Langerhans cells. LCH is primarily instigated by mutations in the mitogen-activated protein kinase (MAPK) signaling pathway, with BRAFV600E and MAP2K1 mutations constituting most cases. ARAF mutations in LCH highlight the heterogeneity of the...
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