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Exploring the role of HLA variants in neuroblastoma susceptibility through whole exome sequencing.

HLA - 1 May 2024

Bonfiglio Ferdinando, Lasorsa Vito Alessandro, Aievola Vincenzo, Cantalupo Sueva, Morini Martina, Ardito Martina, Conte Massimo, Fragola Martina, Eva Alessandra, Corrias Maria Valeria, Iolascon Achille, Capasso Mario

Abstract excerpt

Although a number of susceptibility loci for neuroblastoma (NB) have been identified by genome-wide association studies, it is still unclear whether variants in the HLA region contribute to NB susceptibility. In this study, we conducted a comprehensive genetic analysis of variants in the HLA region among 724 NB patients and 2863 matched controls from different cohorts. We exploited whole-exome sequencing data to...

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PMID: 38747019
DOI: 10.1111/tan.15515

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